Host factors in coronavirus replication
AH De Wilde, EJ Snijder, M Kikkert… - Roles of host gene and …, 2018 - Springer
Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …
The coronavirus nucleocapsid is a multifunctional protein
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic
RNA, interacts with the viral membrane protein during virion assembly and plays a critical …
RNA, interacts with the viral membrane protein during virion assembly and plays a critical …
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Continuous and discontinuous RNA synthesis in coronaviruses
I Sola, F Almazán, S Zúñiga… - Annual review of …, 2015 - annualreviews.org
Replication of the coronavirus genome requires continuous RNA synthesis, whereas
transcription is a discontinuous process unique among RNA viruses. Transcription includes …
transcription is a discontinuous process unique among RNA viruses. Transcription includes …
[HTML][HTML] SARS‐CoV‐2: at the crossroad between aging and neurodegeneration
In December 2019, a pneumonia outbreak associated with a novel form of human
coronavirus was reported in Wuhan, Hubei province, China. 1, 2 As the causative agent of …
coronavirus was reported in Wuhan, Hubei province, China. 1, 2 As the causative agent of …
Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication
Cytoplasmic stress granules (SGs) are generally triggered by stress-induced translation
arrest for storing mRNAs. Recently, it has been shown that SGs exert anti-viral functions due …
arrest for storing mRNAs. Recently, it has been shown that SGs exert anti-viral functions due …
Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling
P V'kovski, M Gerber, J Kelly, S Pfaender, N Ebert… - elife, 2019 - elifesciences.org
Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA
synthesis and a platform for interactions with host proteins. However, little is known about …
synthesis and a platform for interactions with host proteins. However, little is known about …
NAD+ in COVID-19 and viral infections
NAD+, as an emerging regulator of immune responses during viral infections, may be a
promising therapeutic target for coronavirus disease 2019 (COVID-19). In this Opinion, we …
promising therapeutic target for coronavirus disease 2019 (COVID-19). In this Opinion, we …
[HTML][HTML] A proposed role for the SARS‐CoV‐2 nucleocapsid protein in the formation and regulation of biomolecular condensates
To date, the recently discovered SARS‐CoV‐2 virus has afflicted> 6.9 million people
worldwide and disrupted the global economy. Development of effective vaccines or …
worldwide and disrupted the global economy. Development of effective vaccines or …
Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?
Stress granules (SGs) are RNA-containing cytoplasmic foci formed in response to stress
exposure. Since their discovery in 1999, over 120 proteins have been described to be …
exposure. Since their discovery in 1999, over 120 proteins have been described to be …