Hexokinase isoforms I and II bind to mitochondrial outer membranes in large part by
interacting with the outer membrane voltage-dependent anion channel (VDAC). This …

Hexokinase II is often highly expressed in poorly differentiated and rapidly growing tumors
that exhibit a high rate of aerobic glycolysis. Hexokinase II binds to the mitochondrial …

In tumour cells, elevated levels of mitochondria-bound isoforms of hexokinase (HK-I and HK-
II) result in the evasion of apoptosis, thereby allowing the cells to continue proliferating. The …

Alterations in glucose metabolism have been demonstrated for diverse disorders ranging
from heart disease to cancer. The first step in glucose metabolism is carried out by the …

Metabolism sustains life through enzyme-catalyzed chemical reactions within the cells of all
organisms. The coupling of catalytic function to the structural organization of enzymes …

Hexokinase‐II (HKII) is highly expressed in the heart and can bind to the mitochondrial outer
membrane. Since cardiac hypertrophy is associated with a substrate switch from fatty acid to …

Rationale: Cardiomyocytes switch substrate utilization from fatty acid to glucose under
ischemic conditions; however, it is unknown how perturbations in glycolytic enzymes affect …

The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized
through glycolysis or directed to alternative metabolic routes, such as the pentose …

The biology and pathogenesis of hepatitis E virus are poorly understood due to the lack of
an in vitro culture or infection models. The viral Orf3 protein activates the cellular mitogen …

Accumulating evidence has revealed pivotal roles of glycogen synthase kinase-3β (GSK3β)
inactivation on cardiac protection. Because the precise mechanisms of cardiac protection …