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Genome mining methods to discover bioactive natural products
Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
Marine natural products
This review covers the literature published in 2019 for marine natural products (MNPs), with
719 citations (701 for the period January to December 2019) referring to compounds …
719 citations (701 for the period January to December 2019) referring to compounds …
[HTML][HTML] A navigation guide of synthetic biology tools for Pseudomonas putida
Pseudomonas putida is a microbial chassis of huge potential for industrial and
environmental biotechnology, owing to its remarkable metabolic versatility and ability to …
environmental biotechnology, owing to its remarkable metabolic versatility and ability to …
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases
Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
Lipopeptide families at the interface between pathogenic and beneficial Pseudomonas-plant interactions
L Girard, M Höfte, RD Mot - Critical reviews in microbiology, 2020 - Taylor & Francis
Lipopeptides (LPs) are a prominent class of molecules among the steadily growing
spectrum of specialized metabolites retrieved from Pseudomonas, in particular soil-dwelling …
spectrum of specialized metabolites retrieved from Pseudomonas, in particular soil-dwelling …
Unexpected assembly machinery for 4(3H)-quinazolinone scaffold synthesis
XW Chen, L Rao, JL Chen, Y Zou - Nature Communications, 2022 - nature.com
Abstract 4 (3 H)-quinazolinone is the core scaffold in more than 200 natural alkaloids and
numerous drugs. Many chemosynthetic methodologies have been developed to generate it; …
numerous drugs. Many chemosynthetic methodologies have been developed to generate it; …
Unraveling the iterative type I polyketide synthases hidden in Streptomyces
Type I polyketide synthases (T1PKSs) are one of the most extensively studied PKSs, which
can act either iteratively or via an assembly-line mechanism. Domains in the T1PKSs can …
can act either iteratively or via an assembly-line mechanism. Domains in the T1PKSs can …
Engineering of natural product biosynthesis in Pseudomonas putida
A Loeschcke, S Thies - Current opinion in biotechnology, 2020 - Elsevier
Organisms from all kingdoms of life represent a rich source for valuable natural products
with various applications. Microbial systems are useful to implement the expression of …
with various applications. Microbial systems are useful to implement the expression of …
Integrated genome and metabolome mining unveiled structure and biosynthesis of novel lipopeptides from a deep‐sea Rhodococcus
C Ragozzino, F Palma Esposito… - Microbial …, 2024 - Wiley Online Library
Microbial biosurfactants have garnered significant interest from industry due to their lower
toxicity, biodegradability, activity at lower concentrations and higher resistance compared to …
toxicity, biodegradability, activity at lower concentrations and higher resistance compared to …
Heterologous overproduction of oviedomycin by refactoring biosynthetic gene cluster and metabolic engineering of host strain Streptomyces coelicolor
Background Oviedomycin is one among several polyketides known for their potential as
anticancer agents. The biosynthetic gene cluster (BGC) for oviedomycin is primarily found in …
anticancer agents. The biosynthetic gene cluster (BGC) for oviedomycin is primarily found in …