Genome mining methods to discover bioactive natural products

KD Bauman, KS Butler, BS Moore… - Natural product reports, 2021 - pubs.rsc.org
Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Marine natural products

AR Carroll, BR Copp, RA Davis, RA Keyzers… - Natural product …, 2021 - pubs.rsc.org
This review covers the literature published in 2019 for marine natural products (MNPs), with
719 citations (701 for the period January to December 2019) referring to compounds …

[HTML][HTML] A navigation guide of synthetic biology tools for Pseudomonas putida

M Martin-Pascual, C Batianis, L Bruinsma… - Biotechnology …, 2021 - Elsevier
Pseudomonas putida is a microbial chassis of huge potential for industrial and
environmental biotechnology, owing to its remarkable metabolic versatility and ability to …

Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases

KD Patel, MR MacDonald, SF Ahmed, J Singh… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …

Lipopeptide families at the interface between pathogenic and beneficial Pseudomonas-plant interactions

L Girard, M Höfte, RD Mot - Critical reviews in microbiology, 2020 - Taylor & Francis
Lipopeptides (LPs) are a prominent class of molecules among the steadily growing
spectrum of specialized metabolites retrieved from Pseudomonas, in particular soil-dwelling …

Unexpected assembly machinery for 4(3H)-quinazolinone scaffold synthesis

XW Chen, L Rao, JL Chen, Y Zou - Nature Communications, 2022 - nature.com
Abstract 4 (3 H)-quinazolinone is the core scaffold in more than 200 natural alkaloids and
numerous drugs. Many chemosynthetic methodologies have been developed to generate it; …

Unraveling the iterative type I polyketide synthases hidden in Streptomyces

B Wang, F Guo, C Huang, H Zhao - … of the National Academy of Sciences, 2020 - pnas.org
Type I polyketide synthases (T1PKSs) are one of the most extensively studied PKSs, which
can act either iteratively or via an assembly-line mechanism. Domains in the T1PKSs can …

Engineering of natural product biosynthesis in Pseudomonas putida

A Loeschcke, S Thies - Current opinion in biotechnology, 2020 - Elsevier
Organisms from all kingdoms of life represent a rich source for valuable natural products
with various applications. Microbial systems are useful to implement the expression of …

Integrated genome and metabolome mining unveiled structure and biosynthesis of novel lipopeptides from a deep‐sea Rhodococcus

C Ragozzino, F Palma Esposito… - Microbial …, 2024 - Wiley Online Library
Microbial biosurfactants have garnered significant interest from industry due to their lower
toxicity, biodegradability, activity at lower concentrations and higher resistance compared to …

Heterologous overproduction of oviedomycin by refactoring biosynthetic gene cluster and metabolic engineering of host strain Streptomyces coelicolor

B Gu, DG Kim, DK Kim, M Kim, HU Kim, MK Oh - Microbial Cell Factories, 2023 - Springer
Background Oviedomycin is one among several polyketides known for their potential as
anticancer agents. The biosynthetic gene cluster (BGC) for oviedomycin is primarily found in …