Executive summary The 2024 update of the Lancet Commission on dementia provides new
hopeful evidence about dementia prevention, intervention, and care. As people live longer …

Due to the highly evolved industrialization and modernization, air quality has deteriorated in
most countries. As reported by the World Health Organization (WHO), air pollution is now …

Obesity is associated with cognitive decline. Recent observations in mice propose an
adipose tissue (AT)–brain axis. We identified 188 genes from RNA sequencing of AT in …

Many countries are facing the advent of super-aging societies, where sarcopenia and frailty
will become pertinent problems. The prevalence of comorbidities is a major problem in …

Background: Obesity is highly prevalent and disabling, especially in individuals with severe
mental illness including bipolar disorders (BD). The brain is a target organ for both obesity …

Abstract According to the United Nations, by 2050, one in six individuals will be over age 65
globally, and one in four people would be aged 65 and older in western countries. The …

Lipid metabolism disorder is a common pathological manifestation of menopausal women,
and is also an important risk factor for many diseases at this stage of life. Epidemiological …

OBJECTIVE The comparative neuroprotective effects of different antidiabetes drugs have not
been characterized in randomized controlled trials. Here, we investigated the therapeutic …

Background Obesity have been showed to be strongly associated with psychiatric disorders,
but the exact causality and the direction of the relationship remain inconclusive. Thus, we …

Background and Objectives Accumulating evidence connects diverse components of body
composition (eg, fat, muscle, and bone) to neurodegenerative disease risk, yet their interplay …