• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Diabetic foot ulcers (DFU) are a major source of preventable morbidity in adults with
diabetes. Consequences of foot ulcers include decline in functional status, infection …

Importance Approximately 18.6 million people worldwide are affected by a diabetic foot ulcer
each year, including 1.6 million people in the United States. These ulcers precede 80% of …

Chronic nonhealing wounds are one of the major and rapidly growing clinical complications
all over the world. Current therapies frequently require emergent surgical interventions …

Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …