Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Targeting SARS-CoV-2 papain-like protease in the postvaccine era
While vaccines remain at the forefront of global healthcare responses, pioneering
therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid …
therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid …
Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19
Y Lu, Q Yang, T Ran, G Zhang, W Li, P Zhou… - Nature …, 2024 - nature.com
The RNA-dependent RNA polymerase (RdRp), 3C-like protease (3CLpro), and papain-like
protease (PLpro) are pivotal components in the viral life cycle of SARS-CoV-2, presenting as …
protease (PLpro) are pivotal components in the viral life cycle of SARS-CoV-2, presenting as …
Identification of the SARS-unique domain of SARS-CoV-2 as an antiviral target
Abstract SARS-CoV-2 nsp3 is essential for viral replication and host responses. The SARS-
unique domain (SUD) of nsp3 exerts its function through binding to viral and host proteins …
unique domain (SUD) of nsp3 exerts its function through binding to viral and host proteins …
COVID-19 drug discovery and treatment options
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
Targeting papain-like protease by natural products as novel therapeutic potential SARS-CoV-2
The highly infectious respiratory illness 'COVID-19'was caused by SARS-CoV-2 and is
responsible for millions of deaths. SARS-single-stranded viral RNA genome encodes …
responsible for millions of deaths. SARS-single-stranded viral RNA genome encodes …
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity
GR Velma, Z Shen, C Holberg, J Fu… - Journal of Medicinal …, 2024 - ACS Publications
The SARS-CoV-2 papain-like protease (PLpro), essential for viral processing and immune
response disruption, is a promising target for treating acute infection of SARS-CoV-2. To …
response disruption, is a promising target for treating acute infection of SARS-CoV-2. To …
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads
We report here the synthesis and biological evaluation of a series of small molecule SARS-
CoV-2 PLpro inhibitors. We compared the activity of selected compounds in both SARS-CoV …
CoV-2 PLpro inhibitors. We compared the activity of selected compounds in both SARS-CoV …
Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2
The pandemic caused by the coronavirus SARS-CoV-2 led to a global crisis in the world
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …
A Mini-Review on the Common Antiviral Drug Targets of Coronavirus
J Wang, Q Zhu, X **ng, D Sun - Microorganisms, 2024 - mdpi.com
Coronaviruses in general are a zoonotic pathogen with significant cross-species
transmission. They are widely distributed in nature and have recently become a major threat …
transmission. They are widely distributed in nature and have recently become a major threat …