Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …

Background Alzheimer's disease (AD) is an insidious, irreversible, and progressive
neurodegenerative health condition manifesting as cognitive deficits and amyloid beta (Aβ) …

Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

Aggregation of the misfolded proteins β-amyloid, tau, huntingtin, and α-synuclein is one of
the most important steps in the pathology underlying a wide spectrum of neurodegenerative …

The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in
eukaryotes. Herein, we will review advances in the understanding of the role of several …

Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and
universal system for protecting cells and the whole body from various types of stress. Among …

Mounting evidence suggests a link between metabolic syndrome (MetS) such as diabetes,
obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD) …

This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …

Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of
cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids …

The number of the people affected by neurodegenerative disorders is growing dramatically
due to the ageing of population. The major neurodegenerative diseases share some …