T cells are continually generated in the thymus in a highly dynamic process comprising
discrete steps of lineage commitment, T cell receptor (TCR) gene rearrangement, and …

As our catalog of cell states expands, appropriate characterization of these states and the
transitions between them is crucial. Here we discuss the roles of intermediate cell states …

Acute myeloid leukemia (AML) is a paradigmatic example of a stem cell-driven cancer. AML
belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML …

Recent experimental evidence suggests that acute myeloid leukaemias may originate from
multiple clones of malignant cells. Nevertheless, it is not known how the observed clones …

This paper presents a mathematical framework for modeling the dynamics of heterogeneous
populations. Models describing local and non-local growth and transport processes appear …

Hematopoietic stem cells (HSCs) and downstream progenitors have long been studied
based on phenotype, cell purification, proliferation, and transplantation into myeloablated …

By the time the process of oncogenesis has produced an advanced cancer, tumor cells have
undergone extensive evolution. The cellular phenotypes resulting from this evolution have …

Stem cells are fundamental to human life and offer great therapeutic potential, yet their
biology remains incompletely—or in cases even poorly—understood. The field of stem cell …

Neutropenia is a serious toxic complication of chemotherapeutic treatment. For years,
mathematical models have been developed to better predict hematological outcomes during …

Single-cell transcriptomic technologies enable the uncovering and characterization of
cellular heterogeneity and pave the way for studies aiming at understanding the origin and …