Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite
30+ years of intense investigation, the field lacks consensus regarding the etiology and …

Since its identification in 1989, hepatitis C virus (HCV) has emerged as a worldwide health
problem with roughly 185 million chronic infections, representing individuals at high risk of …

Recent studies have linked obesity, type 2 diabetes mellitus (T2DM) or non-alcoholic
steatohepatitis (NASH) to insulin resistance in the brain, cognitive impairment and …

Background and purpose Hepatitis C virus (HCV) infection may cause cognitive impairment,
but no studies have focused specifically on cognitive impairment stemming from HCV. The …

BACKGROUND & AIMS: Chronic hepatitis C virus (HCV) infection is associated with altered
cerebral metabolism and cognitive dysfunction. We aimed to evaluate the effect of pegylated …

Ceramides are lipid signaling molecules that cause cytotoxicity and cell death mediated by
insulin resistance, inflammation, and endoplasmic reticulum (ER) stress. However, insulin …

About 50% of patients with hepatitis C virus (HCV) infection complain of neuropsychiatric
symptoms,“brain fog”, weakness, fatigue, and exhibit some degree of quality of life …

Alcohol abuse causes progressive toxicity and degeneration in liver and brain due to insulin
resistance, which exacerbates oxidative stress and pro-inflammatory cytokine activation …

Chronic alcohol exposure inhibits insulin and insulin‐like growth factor signaling in the liver
and brain by impairing the signaling cascade at multiple levels. These alterations produced …

There is growing evidence that hepatitis C virus (HCV)-infection may affect the brain. About
half of the HCV-infected patients complain of chronic fatigue irrespective of their stage of …