Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Biosynthesis and biological functions of terpenoids in plants

D Tholl - Biotechnology of isoprenoids, 2015 - Springer
<? xm-replace_text {Heading}?> Abstract Terpenoids (isoprenoids) represent the largest
and most diverse class of chemicals among the myriad compounds produced by plants …

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

PK Ajikumar, WH ** enzyme parameters
A Bar-Even, E Noor, Y Savir, W Liebermeister… - Biochemistry, 2011 - ACS Publications
The kinetic parameters of enzymes are key to understanding the rate and specificity of most
biological processes. Although specific trends are frequently studied for individual enzymes …

Manufacturing molecules through metabolic engineering

JD Keasling - Science, 2010 - science.org
Metabolic engineering has the potential to produce from simple, readily available,
inexpensive starting materials a large number of chemicals that are currently derived from …

Systems metabolic engineering of microorganisms for natural and non-natural chemicals

JW Lee, D Na, JM Park, J Lee, S Choi… - Nature chemical biology, 2012 - nature.com
Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of chemicals, fuels …

Improving fatty acids production by engineering dynamic pathway regulation and metabolic control

P Xu, L Li, F Zhang… - Proceedings of the …, 2014 - National Acad Sciences
Global energy demand and environmental concerns have stimulated increasing efforts to
produce carbon-neutral fuels directly from renewable resources. Microbially derived …

Engineering yeast for high-level production of diterpenoid sclareol

X Cao, W Yu, Y Chen, S Yang, ZK Zhao, J Nielsen… - Metabolic …, 2023 - Elsevier
The diterpenoid sclareol is an industrially important precursor for alternative sustainable
supply of ambergris. However, its current production from plant extraction is neither …

Structure, synthesis, biosynthesis, and activity of the characteristic compounds from Ginkgo biloba L.

XG Liu, X Lu, W Gao, P Li, H Yang - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 1928–2021 Ginkgo biloba L. is one of the most distinctive plants to have emerged
on earth and has no close living relatives. Owing to its phylogenetic divergence from other …