Contractile force assessment methods for in vitro skeletal muscle tissues

C Vesga-Castro, J Aldazabal, A Vallejo-Illarramendi… - Elife, 2022 - elifesciences.org
Over the last few years, there has been growing interest in measuring the contractile force
(CF) of engineered muscle tissues to evaluate their functionality. However, there are still no …

Long-term stability of aerophilic metallic surfaces underwater

AB Tesler, S Kolle, LH Prado, I Thievessen… - Nature Materials, 2023 - nature.com
Aerophilic surfaces immersed underwater trap films of air known as plastrons. Plastrons
have typically been considered impractical for underwater engineering applications due to …

The evolution of complex muscle cell in vitro models to study pathomechanisms and drug development of neuromuscular disease

J Zschüntzsch, S Meyer, M Shahriyari, K Kummer… - Cells, 2022 - mdpi.com
Many neuromuscular disease entities possess a significant disease burden and therapeutic
options remain limited. Innovative human preclinical models may help to uncover relevant …

Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation

H Li, Y Zheng, YL Han, S Cai, M Guo - Proceedings of the National …, 2021 - pnas.org
Basement membrane (BM) is a thin layer of extracellular matrix that surrounds most animal
tissues, serving as a physical barrier while allowing nutrient exchange. Although they have …

Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility

D Böhringer, A Bauer, I Moravec, L Bischof, D Kah… - Matrix Biology, 2023 - Elsevier
Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment
that induce deformations and remodeling of the fiber network. By measuring these …

Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

AD Hofemeier, T Limon, TM Muenker, B Wallmeyer… - Elife, 2021 - elifesciences.org
Tension and mechanical properties of muscle tissue are tightly related to proper skeletal
muscle function, which makes experimental access to the biomechanics of muscle tissue …

Corrosion Resistance of Biodegradable Zinc Surfaces Enhanced by UV-Grafted Polydimethylsiloxane Coating

D Pupillo, MP Bruns, LH Prado… - ACS Biomaterials …, 2024 - ACS Publications
Improved living conditions have led to an increase in life expectancy worldwide. However,
as people age, the risk of vascular disease tends to increase due to the accumulation and …

The desmin mutation R349P increases contractility and fragility of stem cell‐generated muscle micro‐tissues

M Spörrer, D Kah, RC Gerum, B Reischl… - Neuropathology and …, 2022 - Wiley Online Library
Aims Desminopathies comprise hereditary myopathies and cardiomyopathies caused by
mutations in the intermediate filament protein desmin that lead to severe and often lethal …

[HTML][HTML] The Development of an Innovative Embedded Sensor for the Optical Measurement of Ex-Vivo Engineered Muscle Tissue Contractility

L Apa, M Cosentino, F Forconi, A Musarò, E Rizzuto… - Sensors, 2022 - mdpi.com
Tissue engineering is a multidisciplinary approach focused on the development of
innovative bioartificial substitutes for damaged organs and tissues. For skeletal muscle, the …

Real‐Time Force Monitoring of Electrically Stimulated 3D‐Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity

S Lai, J Fuentes, M Guix, G Casula… - Advanced Intelligent …, 2024 - Wiley Online Library
The contractile nature of skeletal muscle tissue makes it especially attractive for powering
biohybrid actuators. Significant efforts have been dedicated to the improvement and control …