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Blood vessel organoids for development and disease
Despite enormous advances, cardiovascular disorders are still a major threat to global
health and are responsible for one-third of deaths worldwide. Research for new therapeutics …
health and are responsible for one-third of deaths worldwide. Research for new therapeutics …
Detection, risk factors, and functional consequences of cerebral microinfarcts
Cerebral microinfarcts are small lesions that are presumed to be ischaemic. Despite the
small size of these lesions, affected individuals can have hundreds to thousands of cerebral …
small size of these lesions, affected individuals can have hundreds to thousands of cerebral …
Brain capillary pericytes exert a substantial but slow influence on blood flow
The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex
Smooth muscle cells and pericytes, together called mural cells, coordinate many distinct
vascular functions. Canonically, smooth muscle cells are ring-shaped and cover arterioles …
vascular functions. Canonically, smooth muscle cells are ring-shaped and cover arterioles …
Pericytes as inducers of rapid, matrix metalloproteinase-9-dependent capillary damage during ischemia
Blood–brain barrier disruption (BBB) and release of toxic blood molecules into the brain
contributes to neuronal injury during stroke and other cerebrovascular diseases. While …
contributes to neuronal injury during stroke and other cerebrovascular diseases. While …
Imaging the construction of capillary networks in the neonatal mouse brain
Capillary networks are essential for distribution of blood flow through the brain, and
numerous other homeostatic functions, including neurovascular signal conduction and …
numerous other homeostatic functions, including neurovascular signal conduction and …
Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: a hyperacute role for neutrophils in persistent traffic jams
Ever since the introduction of thrombolysis and the subsequent expansion of endovascular
treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are …
treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are …
Cerebral microinfarcts revisited: detection, causes, and clinical relevance
Cerebral microinfarcts (CMIs) are small ischemic lesions invisible to the naked eye at brain
autopsy, while the larger ones (0.5–4 mm in diameter) have been visualized in-vivo on …
autopsy, while the larger ones (0.5–4 mm in diameter) have been visualized in-vivo on …
A window of vascular plasticity coupled to behavioral recovery after stroke
Stroke causes remodeling of vasculature surrounding the infarct, but whether and how
vascular remodeling contributes to recovery are unclear. We established an approach to …
vascular remodeling contributes to recovery are unclear. We established an approach to …
Cerebral small vessel disease (CSVD)–lessons from the animal models
Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings
resulting from pathological processes of various etiologies affecting cerebral arterioles …
resulting from pathological processes of various etiologies affecting cerebral arterioles …