Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

The functions and unique features of long intergenic non-coding RNA

JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers

Y Li, T Jiang, W Zhou, J Li, X Li, Q Wang, X **… - Nature …, 2020 - nature.com
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression
and they play fundamental roles in immune regulation. Here we introduce an integrated …

[HTML][HTML] The translational landscape of the human heart

S Van Heesch, F Witte, V Schneider-Lunitz, JF Schulz… - Cell, 2019 - cell.com
Gene expression in human tissue has primarily been studied on the transcriptional level,
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …

Mechanisms of long noncoding RNA function in development and disease

SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

X Hu, WX Peng, H Zhou, J Jiang, X Zhou… - Cell Death & …, 2020 - nature.com
The major function of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is to
regulate cell metabolism. However, emerging evidence indicates that IGF2BP2 plays a role …

Long noncoding RNA in cancer: wiring signaling circuitry

C Lin, L Yang - Trends in cell biology, 2018 - cell.com
Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the
human genome, may hold missing drivers of cancer and have gained attention recently as a …

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides

KA Lennox, MA Behlke - Nucleic acids research, 2016 - academic.oup.com
Thousands of long non-coding RNAs (lncRNAs) have been identified in mammalian cells.
Some have important functions and their dysregulation can contribute to a variety of disease …

[HTML][HTML] The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse

P Grote, L Wittler, D Hendrix, F Koch, S Währisch… - Developmental cell, 2013 - cell.com
The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the
activation state of genes controlling pluripotency, lineage commitment, and cell …

Lung development: orchestrating the generation and regeneration of a complex organ

M Herriges, EE Morrisey - Development, 2014 - journals.biologists.com
The respiratory system, which consists of the lungs, trachea and associated vasculature, is
essential for terrestrial life. In recent years, extensive progress has been made in defining …