Halogenated antimicrobial agents to combat drug-resistant pathogens
Antimicrobial resistance presents us with a potential global crisis as it undermines the
abilities of conventional antibiotics to combat pathogenic microbes. The history of …
abilities of conventional antibiotics to combat pathogenic microbes. The history of …
An insight into the mechanism of antibacterial activity by magnesium oxide nanoparticles
The exact mechanism behind the antibacterial efficacy of nanoparticles has remained
unexplored to date. This study aims to shed light the mechanism adopted using magnesium …
unexplored to date. This study aims to shed light the mechanism adopted using magnesium …
β-lactamase-mediated fragmentation: historical perspectives and recent advances in diagnostics, imaging, and antibacterial design
The discovery of β-lactam (BL) antibiotics in the early 20th century represented a remarkable
advancement in human medicine, allowing for the widespread treatment of infectious …
advancement in human medicine, allowing for the widespread treatment of infectious …
Modular synthetic routes to fluorine-containing halogenated phenazine and acridine agents that induce rapid iron starvation in methicillin-resistant Staphylococcus …
During infection, bacteria use an arsenal of resistance mechanisms to negate antibiotic
therapies. In addition, pathogenic bacteria form surface-attached biofilms bearing enriched …
therapies. In addition, pathogenic bacteria form surface-attached biofilms bearing enriched …
A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents
H Yang, S Kundra, M Chojnacki, K Liu… - Journal of medicinal …, 2021 - ACS Publications
Pathogenic bacteria demonstrate incredible abilities to evade conventional antibiotics
through the development of resistance and formation of dormant, surface-attached biofilms …
through the development of resistance and formation of dormant, surface-attached biofilms …
Design, synthesis and evaluation of halogenated phenazine antibacterial prodrugs targeting nitroreductase enzymes for activation
It is of great importance to develop new strategies to combat antibiotic resistance. Our lab
has discovered halogenated phenazine (HP) analogues that are highly active against …
has discovered halogenated phenazine (HP) analogues that are highly active against …
Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications
H Yang, K Liu, S **, RW Huigens III - Organic & biomolecular …, 2021 - pubs.rsc.org
There is a significant need for new antibacterial agents as pathogenic bacteria continue to
threaten human health through the acquisition of resistance and tolerance towards existing …
threaten human health through the acquisition of resistance and tolerance towards existing …
Strategies and approaches for discovery of small molecule disruptors of biofilm physiology
Biofilms, the predominant growth mode of microorganisms, pose a significant risk to human
health. The protective biofilm matrix, typically composed of exopolysaccharides, proteins …
health. The protective biofilm matrix, typically composed of exopolysaccharides, proteins …
An ether-linked halogenated phenazine-quinone prodrug model for antibacterial applications
Antibiotic-resistant infections present significant challenges to patients. As a result, there is
considerable need for new antibacterial therapies that eradicate pathogenic bacteria …
considerable need for new antibacterial therapies that eradicate pathogenic bacteria …
The silver-mediated annulation of arylcarbamic acids and nitrosoarenes toward phenazines
L Wang, F Chen, PC Qian, J Cheng - Tetrahedron Letters, 2022 - Elsevier
A silver-mediated annulation between arylcarbamic acids and nitrosoarenes was
developed, leading to phenazines in moderate to good yields with complexity and diversity …
developed, leading to phenazines in moderate to good yields with complexity and diversity …