Towards clinical translation of FLASH radiotherapy

MC Vozenin, J Bourhis, M Durante - Nature Reviews Clinical Oncology, 2022 - nature.com
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

FLASH: New intersection of physics, chemistry, biology, and cancer medicine

MC Vozenin, BW Loo Jr, S Tantawi, PG Maxim… - Reviews of Modern …, 2024 - APS
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …

Absolute dosimetry for FLASH proton pencil beam scanning radiotherapy

A Lourenço, A Subiel, N Lee, S Flynn, J Cotterill… - Scientific Reports, 2023 - nature.com
A paradigm shift is occurring in clinical oncology exploiting the recent discovery that short
pulses of ultra-high dose rate (UHDR) radiation—FLASH radiotherapy—can significantly …

Mechanisms of action in FLASH radiotherapy: A comprehensive review of physicochemical and biological processes on cancerous and normal cells

JCL Chow, HE Ruda - Cells, 2024 - mdpi.com
The advent of FLASH radiotherapy (FLASH-RT) has brought forth a paradigm shift in cancer
treatment, showcasing remarkable normal cell sparing effects with ultra-high dose rates (> …

[HTML][HTML] FLASH radiotherapy and the use of radiation dosimeters

S Siddique, HE Ruda, JCL Chow - Cancers, 2023 - mdpi.com
Simple Summary FLASH radiotherapy (RT) delivering ultra-high dose rate radiation can
reduce normal tissue toxicity while effectively treating tumors. However, implementing …

Metal-based nanoparticle in cancer treatment: lessons learned and challenges

A Hheidari, J Mohammadi, M Ghodousi… - … in Bioengineering and …, 2024 - frontiersin.org
Cancer, being one of the deadliest diseases, poses significant challenges despite the
existence of traditional treatment approaches. This has led to a growing demand for …

Framework for quality assurance of ultrahigh dose rate clinical trials investigating FLASH effects and current technology gaps

W Zou, R Zhang, E Schüler, PA Taylor… - International Journal of …, 2023 - Elsevier
Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …

Dual beam‐current transformer design for monitoring and reporting of electron ultra‐high dose rate (FLASH) beam parameters

K Liu, A Palmiero, N Chopra… - Journal of applied …, 2023 - Wiley Online Library
Purpose To investigate the usefulness and effectiveness of a dual beam‐current transformer
(BCTs) design to monitor and record the beam dosimetry output and energy of pulsed …

Flash radiotherapy: Innovative cancer treatment

JCL Chow, HE Ruda - Encyclopedia, 2023 - mdpi.com
Definition Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for
cancer treatment because it delivers an extremely high dose of radiation (> 40 Gy/s) to the …

Evaluation of ion chamber response for applications in electron FLASH radiotherapy

K Liu, S Holmes, B Hooten, E Schüler… - Medical …, 2024 - Wiley Online Library
Ion chambers are required for calibration and reference dosimetry applications in radiation
therapy (RT). However, exposure of ion chambers in ultra‐high dose rate (UHDR) conditions …