Complement regulators and inhibitory proteins
PF Zipfel, C Skerka - Nature Reviews Immunology, 2009 - nature.com
The complement system is important for cellular integrity and tissue homeostasis.
Complement activation mediates the removal of microorganisms and the clearance of …
Complement activation mediates the removal of microorganisms and the clearance of …
Therapeutic targeting of the complement system: from rare diseases to pandemics
The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …
plasma component that “complemented” the antibodies in killing microbes, hence the name …
Complement activation, regulation, and molecular basis for complement‐related diseases
The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …
becomes activated upon recognition of molecular patterns associated with microorganisms …
Complement and its receptors: new insights into human disease
VM Holers - Annual review of immunology, 2014 - annualreviews.org
Although new activation and regulatory mechanisms are still being identified, the basic
architecture of the complement system has been known for decades. Two major roles of …
architecture of the complement system has been known for decades. Two major roles of …
Inflammation, NF-κB, and chronic diseases: how are they linked?
Most chronic diseases, caused by lifestyle factors, appear to be linked to inflammation.
Inflammation is activated mechanistically, and nuclear factor-κB (NF-κB) is a significant …
Inflammation is activated mechanistically, and nuclear factor-κB (NF-κB) is a significant …
Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition
The protein C system provides important control of blood coagulation by regulating the
activities of factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and …
activities of factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and …
Analysis of the complement system in the clinical immunology laboratory
M Ling, M Murali - Clinics in laboratory medicine, 2019 - labmed.theclinics.com
The discovery of complement dates to the late 1800s, when Jules Bordet identified an
unknown heat-labile lytic substance in blood that possessed activity against various forms of …
unknown heat-labile lytic substance in blood that possessed activity against various forms of …
[HTML][HTML] The anticoagulant protein C pathway
The anticoagulant protein C system regulates the activity of coagulation factors VIIIa and Va,
cofactors in the activation of factor X and prothrombin, respectively. Protein C is activated on …
cofactors in the activation of factor X and prothrombin, respectively. Protein C is activated on …
The role of complement in tumor growth
Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …
Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation
The complement system plays a pivotal protective role in the innate immune response to
many pathogens including flaviviruses. Flavivirus nonstructural protein 1 (NS1) is a secreted …
many pathogens including flaviviruses. Flavivirus nonstructural protein 1 (NS1) is a secreted …