A role for somatic mutations in carcinogenesis is well accepted, but the degree to which
mutation rates influence cancer initiation and development is under continuous debate …

Because germline mutations are the source of all evolutionary adaptations and heritable
diseases, characterizing their properties and the rate at which they arise across individuals …

2). For instance, in this setting with m= 10 and q= 10, IDA found 4, 4, 5, 1 and 2 true positives
for the five different networks, whereas Lasso found 1, 1, 0, 1 and 2 true positives and Elastic …

Mutations create variation in the population, fuel evolution and cause genetic diseases.
Current knowledge about de novo mutations is incomplete and mostly indirect,,,,,,,,,. Here we …

The origin of mutations is central to understanding evolution and of key relevance to health.
Variation occurs non-randomly across the genome, and mechanisms for this remain to be …

Starting with early crucial discoveries of the role of the major histocompatibility complex,
genetic studies have long had a role in understanding the biology of type 1 diabetes (T1D) …

As both natural selection and population history can affect genome-wide patterns of
variation, disentangling the contributions of each has remained as a major challenge in …

Mutational heterogeneity must be taken into account when reconstructing evolutionary
histories, calibrating molecular clocks, and predicting links between genes and disease …

Utilizing the full power of next-generation sequencing often requires the ability to perform
large-scale multiplex enrichment of many specific genomic loci in multiple samples. Several …

We analyzed functionality and relative distribution of genetic variants across the complete
Oryza sativa genome, using the 40 million single nucleotide polymorphisms (SNPs) dataset …