Depression is the most prevalent psychiatric disorder in the world, affecting 4.4% of the
global population. Despite an array of treatment modalities, depressive disorders remain …

Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …

Importance Opioid-related mortality and national prescribing guidelines have led to tapering
of doses among patients prescribed long-term opioid therapy for chronic pain. There is …

Opioid overdoses, many of which are attributed to use of illicit fentanyl, are currently one of
the leading causes of death in the US Although fentanyl has been used safely for decades in …

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for
minutes to hours. However, the neural basis for this effect is unclear, and the underlying …

G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …

Etonitazene and related 2-benzylbenzimidazoles are potent analgetics invented in the
research laboratories of the Swiss pharmaceutical giant CIBA in the late 1950s. Though the …

Context: In recent years, due to an alarming increase in the number of opioid-related
overdose fatalities for White, Non-Hispanics in rural and suburban communities across the …

Transmembrane Cav2. 2 (N-type) voltage-gated calcium channels are genetically and
pharmacologically validated, clinically relevant pain targets. Clinical block of Cav2. 2 (eg …

Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-
based antidepressants were the first drugs developed to treat major depressive disorder …