Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and
a largely untreatable cause of intracerebral haemorrhage and contributor to age-related …

Vascular dementia (VaD) is widely recognised as the second most common type of
dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide …

Vascular dementia (VaD) is recognised as a neurocognitive disorder, which is explained by
numerous vascular causes in the general absence of other pathologies. The heterogeneity …

Amyloid fibers and oligomers are associated with a great variety of human diseases
including Alzheimer's disease and the prion conditions. Here we attempt to connect recent …

Neurodegenerative diseases (NDDs) are characterized by selective dysfunction and loss of
neurons associated with pathologically altered proteins that deposit in the human brain but …

Cerebral amyloid angiopathy (CAA) involves cerebrovascular amyloid deposition and is
classified into several types according to the amyloid protein involved. Of these, sporadic …

Neurodegenerative diseases are characterised by selective dysfunction and progressive
loss of synapses and neurons associated with pathologically altered proteins that deposit …

Sporadic cerebral amyloid angiopathy (CAA) is a common age related cerebral small vessel
disease, characterised by progressive deposition of amyloid-β (Aβ) in the wall of small to …

Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-
functional interface, the blood-brain barrier (BBB). The endothelium is regulated by …