Investigations on the interface of nucleic acid aptamers and binding targets
Nucleic acid aptamers are single-stranded DNA or RNA of 20–100 nucleotides in length that
have attracted substantial scientific interest due to their ability to specifically bind to target …
have attracted substantial scientific interest due to their ability to specifically bind to target …
Review on the selection of aptamers and application in paper-based sensors
K Wang, M Wang, T Ma, W Li, H Zhang - Biosensors, 2022 - mdpi.com
An aptamer is a synthetic oligonucleotide, referring to a single-stranded deoxyribonucleic
acid or ribonucleic acid ligand produced by synthesis from outside the body using …
acid or ribonucleic acid ligand produced by synthesis from outside the body using …
Perspective on the future role of aptamers in analytical chemistry
It has been almost 30 years since the invention of Systematic Evolution of Ligands by
Exponential Enrichment (SELEX) methodology and the description of the first aptamers. In …
Exponential Enrichment (SELEX) methodology and the description of the first aptamers. In …
Chemistry and biology of self-cleaving ribozymes
RM Jimenez, JA Polanco, A Lupták - Trends in biochemical sciences, 2015 - cell.com
Self-cleaving ribozymes were discovered 30 years ago, but their biological distribution and
catalytic mechanisms are only beginning to be defined. Each ribozyme family is defined by a …
catalytic mechanisms are only beginning to be defined. Each ribozyme family is defined by a …
Advances in aptamer screening technologies
Systematic evolution of ligands by exponential enrichment (SELEX) is a well-established
technology for the screening of aptamers binding to various targets with relatively high …
technology for the screening of aptamers binding to various targets with relatively high …
In silico molecular docking in DNA aptamer development
Aptamers are single-stranded DNA or RNA oligonucleotides generated by SELEX that
exhibit binding affinity and specificity against a wide variety of target molecules. Compared …
exhibit binding affinity and specificity against a wide variety of target molecules. Compared …
The ubiquitous hammerhead ribozyme
The hammerhead ribozyme is a small catalytic RNA motif capable of endonucleolytic (self-)
cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three …
cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three …
Transcription factor clusters regulate genes in eukaryotic cells
Transcription is regulated through binding factors to gene promoters to activate or repress
expression, however, the mechanisms by which factors find targets remain unclear. Using …
expression, however, the mechanisms by which factors find targets remain unclear. Using …
HDV-like self-cleaving ribozymes
CHT Webb, A Lupták - RNA biology, 2011 - Taylor & Francis
HDV ribozymes catalyze their own scission from the transcript during rolling circle replication
of the hepatitis delta virus. In vitro selection of self-cleaving ribozymes from a human …
of the hepatitis delta virus. In vitro selection of self-cleaving ribozymes from a human …
3′ Cap-independent translation enhancers of positive-strand RNA plant viruses
BL Nicholson, KA White - Current opinion in virology, 2011 - Elsevier
Positive-strand RNA plant viruses that are neither 5′-capped nor 3′-polyadenylated use
nontraditional mechanisms to recruit ribosomes to the 5′-end of their viral genomes. One …
nontraditional mechanisms to recruit ribosomes to the 5′-end of their viral genomes. One …