Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance
between reactive oxygen and nitrogen species in the body and its ability to neutralize them …

NADPH oxidases (NOXs) form a family of electron-transporting membrane enzymes whose
main function is reactive oxygen species (ROS) generation. Strong evidence suggests that …

NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen
species (ROS). Numerous homologue-specific mechanisms control the activity of this …

Oxidative stress, mainly contributed by reactive oxygen species (ROS), has been implicated
in pathogenesis of several diseases. We review two primary examples; fibrosis and cancer …

Oxidative stress is now recognized as a major predisposing factor in the pathogenesis of
COPD. Existing therapies for COPD are ineffective at halting disease progression, with …

Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production
versus consumption, may be involved in the pathogenesis of different diseases. The only …

Significance: Reactive oxygen species (ROS) play a critical role in vascular disease. While
there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate …

Background NADPH oxidases (NOX) are a family of flavoenzymes that catalyze the
formation of superoxide anion radical (O 2•-) and/or hydrogen peroxide (H 2 O 2). As major …

Two goals motivate treating diseases with drug combinations: reduce off-target toxicity by
minimizing doses (synergistic potency) and improve outcomes by escalating effect …

Reactive oxygen species (ROS) are cellular signals but also disease triggers; their relative
excess (oxidative stress) or shortage (reductive stress) compared to reducing equivalents …