Ferroptosis is an iron-dependent cell death with the accumulation of lipid peroxidation and
dysfunction of antioxidant systems. As the critical regulator, glutathione peroxidase 4 (GPX4) …

The identification of new members in the Cdk and cyclin families, functions for many of which
are still emerging, has added new facets to the cell cycle regulatory network. With roles …

The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely
as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development …

Cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation. Genetic analysis in
mice has revealed an essential role for Cdk2 in meiosis, which renders Cdk2 knockout (KO) …

Cyclin‐dependent kinases (Cdks) are principal drivers of cell division and are an important
therapeutic target to inhibit aberrant proliferation. Cdk enzymatic activity is tightly controlled …

African swine fever (ASF) has emerged as a threat to swine production worldwide. Evasion
of host immunity by ASF virus (ASFV) is well understood. However, the role of ASFV in …

Background Breast cancer (BC) is one of the most common cancers with high mortality
worldwide. In the present study, through bioinformatics analysis, we aimed to identify new …

The heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and
treatment. Identifying and targeting populations of cells driving tumorigenesis is a top priority …

Purpose c-Myc is frequently upregulated in breast cancers, however, targeting c-Myc has
proven to be a challenge. Targeting of downstream mediators of c-Myc, such as the 'cyclin …

Cyclin-dependent kinases (CDKs) require the binding to a regulatory subunit to acquire
enzymatic activity, and cyclins are the canonical CDK activators. However, there are specific …