The membrane surface as a platform that organizes cellular and biochemical processes
Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …
and organelles. In addition, their surfaces actively participate in biochemical reaction …
[HTML][HTML] Computational modeling of membrane trafficking processes: From large molecular assemblies to chemical specificity
In the last decade, molecular dynamics (MD) simulations have become an essential tool to
investigate the molecular properties of membrane trafficking processes, often in conjunction …
investigate the molecular properties of membrane trafficking processes, often in conjunction …
In situ architecture of the ER–mitochondria encounter structure
The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane
biogenesis that rely on lipid exchange via membrane contact sites,–, but the underpinning …
biogenesis that rely on lipid exchange via membrane contact sites,–, but the underpinning …
In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts
VPS13 is a eukaryotic lipid transport protein localized at membrane contact sites. Previous
studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like …
studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like …
Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins
A Arora, JH Taskinen, VM Olkkonen - Progress in lipid research, 2022 - Elsevier
Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute one of the
largest families of lipid-binding/transfer proteins (LTPs) in eukaryotes. The current view is …
largest families of lipid-binding/transfer proteins (LTPs) in eukaryotes. The current view is …
VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites
M Subra, M Dezi, J Bigay, S Lacas-Gervais… - Developmental cell, 2023 - cell.com
Membrane contact sites (MCSs) are heterogeneous in shape, composition, and dynamics.
Despite this diversity, VAP proteins act as receptors for multiple FFAT motif-containing …
Despite this diversity, VAP proteins act as receptors for multiple FFAT motif-containing …
[HTML][HTML] Piecing together the structural organisation of lipid exchange at membrane contact sites
R Khaddaj, W Kukulski - Current opinion in cell biology, 2023 - Elsevier
Membrane contact sites (MCSs) are areas of close proximity between organelles, implicated
in transport of small molecules and in organelle biogenesis. Lipid transfer proteins at MCSs …
in transport of small molecules and in organelle biogenesis. Lipid transfer proteins at MCSs …
Transport pathways that contribute to the cellular distribution of phosphatidylserine
Phosphatidylserine (PS) is a negatively charged phospholipid that displays a highly uneven
distribution within cellular membranes, essential for establishment of cell polarity and other …
distribution within cellular membranes, essential for establishment of cell polarity and other …
An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis
W Zhong, W Lin, Y Yang, D Chen, X Cao, M Xu… - Nature …, 2022 - nature.com
Lipid remodeling is crucial for malignant cell transformation and tumorigenesis, but the
precise molecular processes involved and direct evidences for these in vivo remain elusive …
precise molecular processes involved and direct evidences for these in vivo remain elusive …
Getting to grips with the oxysterol-binding protein family–a forty year perspective
VM Olkkonen, E Ikonen - Contact, 2024 - journals.sagepub.com
This review discusses how research around the oxysterol-binding protein family has
evolved. We briefly summarize how this protein family, designated OSBP-related (ORP) or …
evolved. We briefly summarize how this protein family, designated OSBP-related (ORP) or …