Naturally evolved organisms typically have large genomes that enable their survival and
growth under various conditions. However, the complexity of genomes often precludes our …

Microbial experimental evolution uses controlled laboratory populations to study the
mechanisms of evolution. The molecular analysis of evolved populations enables empirical …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

The origin of biological diversity, via the formation of new species, can be inextricably linked
to adaptation to the ecological environment. Specifically, ecological processes are central to …

We describe the draft genome of the microcrustacean Daphnia pulex, which is only 200
megabases and contains at least 30,907 genes. The high gene count is a consequence of …

Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …

The budding yeast, S accharomyces cerevisiae, is a leading system in genetics, genomics
and molecular biology and is becoming a powerful tool to illuminate ecological and …

Motivation Proteins are essential macromolecules of life and thus understanding their
function is of great importance. The number of functionally unclassified proteins is large …

Over the past few years, genome sequences have become available from an increasing
range of yeast species, which has led to notable advances in our understanding of …

Phenotypic plasticity is the development of different phenotypes from a single genotype,
depending on the environment. Such plasticity is a pervasive feature of life, is observed for …