Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets
Because G-protein coupled receptors (GPCRs) continue to represent excellent targets for
the discovery and development of small-molecule therapeutics, it is posited that additional …
the discovery and development of small-molecule therapeutics, it is posited that additional …
Testing the autonomic nervous system
R Freeman, MW Chapleau - Handbook of clinical neurology, 2013 - Elsevier
Autonomic testing is used to define the role of the autonomic nervous system in diverse
clinical and research settings. Because most of the autonomic nervous system is …
clinical and research settings. Because most of the autonomic nervous system is …
Transcriptomic profiling of the develo** cardiac conduction system at single-cell resolution
Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …
cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of
the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate …
the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate …
Genetic loci associated with heart rate variability and their effects on cardiac disease risk
IM Nolte, ML Munoz, V Tragante, AT Amare… - Nature …, 2017 - nature.com
Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with
greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide …
greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide …
RGS6 suppresses TGF-β-induced epithelial–mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4
Z Wang, J Chen, S Wang, Z Sun, Z Lei, HT Zhang… - Cell Death & …, 2022 - nature.com
Regulator of G-protein signaling 6 (RGS6) is a newly discovered tumor suppressor that has
been shown to be protective in development of various cancers such as breast cancer and …
been shown to be protective in development of various cancers such as breast cancer and …
Neuronal G protein-gated K+ channels
H Luo… - American Journal of …, 2022 - journals.physiology.org
G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …
From two competing oscillators to one coupled-clock pacemaker cell system
Y Yaniv, EG Lakatta, VA Maltsev - Frontiers in physiology, 2015 - frontiersin.org
At the beginning of this century, debates regarding “what are the main control mechanisms
that ignite the action potential (AP) in heart pacemaker cells” dominated the …
that ignite the action potential (AP) in heart pacemaker cells” dominated the …
Deep learning-derived cardiovascular age shares a genetic basis with other cardiac phenotypes
Artificial intelligence (AI)-based approaches can now use electrocardiograms (ECGs) to
provide expert-level performance in detecting heart abnormalities and diagnosing disease …
provide expert-level performance in detecting heart abnormalities and diagnosing disease …
Modern concepts concerning the origin of the heartbeat
O Monfredi, VA Maltsev, EG Lakatta - Physiology, 2013 - journals.physiology.org
Physiological processes governing the heart beat have been under investigation for several
hundred years. Major advances have been made in the recent past. A review of the present …
hundred years. Major advances have been made in the recent past. A review of the present …