The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases

P Dusek, PM Roos, T Litwin, SA Schneider… - Journal of trace …, 2015 - Elsevier
Impaired cellular homeostasis of metals, particularly of Cu, Fe and Mn may trigger
neurodegeneration through various mechanisms, notably induction of oxidative stress …

Speciation analysis and fractionation of manganese: A review

E Grygo-Szymanko, A Tobiasz, S Walas - TrAC Trends in Analytical …, 2016 - Elsevier
Manganese as an essential element is required by organisms from simple bacteria to plants,
animals and human beings. The identification and determination of organic or inorganic …

Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H‐Ferritin

V Venkataramani, TR Doeppner… - Journal of …, 2018 - Wiley Online Library
For more than 150 years, it is known that occupational overexposure of manganese (Mn)
causes movement disorders resembling Parkinson's disease (PD) and PD‐like syndromes …

Simultaneous quantification and speciation of trace metals in paired serum and CSF samples by size exclusion chromatography–inductively coupled plasma–dynamic …

B Michalke, A Berthele, V Venkataramani - International journal of …, 2021 - mdpi.com
Background: Transition metals play a crucial role in brain metabolism: since they exist in
different oxidation states they are involved in ROS generation, but they are also co-factors of …

Manganese speciation in paired serum and CSF samples using SEC-DRC-ICP-MS and CE-ICP-DRC-MS

B Michalke, M Lucio, A Berthele, B Kanawati - Analytical and bioanalytical …, 2013 - Springer
Occupational manganese (Mn) overexposure leads to accumulation in the brain and has
been shown to cause progressive, permanent, neuro-degenerative damage with syndromes …

Separative techniques for metalloproteomics require balance between separation and perturbation

A Hagège, TNS Huynh, M Hébrant - TrAC Trends in Analytical Chemistry, 2015 - Elsevier
Metal-binding proteins play a crucial role in biological systems and associated metals
display many critical functions, so many analytical tools have been developed to identify …

An approach for manganese biomonitoring using a manganese carrier switch in serum from transferrin to citrate at slightly elevated manganese concentration

B Michalke, L Aslanoglou… - Journal of Trace …, 2015 - Elsevier
After high-dose-short-term exposure (usually from occupational exposure) and even more
under low-dose long term exposure (mainly environmental) manganese (Mn) biomonitoring …

Определение химических форм микроэлементов в биологических объектах

НБ Иваненко, НД Соловьев, АА Иваненко… - Аналитика и контроль …, 2012 - elar.urfu.ru
Обобщен опыт определения химических форм микроэлементов в биологических
объектах, основное внимание уделено клиническим объектам анализа. Обсуждены …

[HTML][HTML] Prolidase activity assays. A survey of the reported literature methodologies

S Fiorito, S Genovese, F Epifano, C Collevecchio - Analytical Biochemistry, 2024 - Elsevier
Abstract Prolidase (EC. 3.4. 13.9) is a dipeptidase known nowadays to play a pivotal role in
several physiological and pathological processes. More in particular, this enzyme is …

Manganese and iron species in Sprague–Dawley rats exposed with MnCl2∙ 4H2O (iv)

J Diederich, M Brielmeier, T Schwerdtle… - Microchemical Journal, 2012 - Elsevier
Chronic manganese exposure leads to accumulation in brain mainly in the basal ganglia.
Continuous incorporation finally causes neural damage (Manganism, Mn-PD) with disease …