The life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) consists of two phases,
latent and lytic. The virus establishes latency as a strategy for avoiding host immune …

Sp1 and Sp3 are transcription factors expressed in all mammalian cells. These factors are
involved in regulating the transcriptional activity of genes implicated in most cellular …

Previous research has suggested that human herpesvirus-6 (HHV-6) may integrate into host
cell chromosomes and be vertically transmitted in the germ line, but the evidence—primarily …

Host cell metabolism is essential for the viral replication cycle and, therefore, for productive
infection. Energy (ATP) is required for the receptor-mediated attachment of viral particles to …

Recombinant adeno-associated virus (rAAV) vectors are capable of mediating long-term
gene expression following administration to skeletal muscle. In rodent muscle, the vector …

La famille de facteurs de transcription Sp partage une combinaison particulière de trois
motifs à doigts de zinc Cys2His2 qui forment le domaine spécifique de liaison à l'ADN. Au …

Epigenetic modifications of the herpesviral genome play a key role in the transcriptional
control of latent and lytic genes during a productive viral lifecycle. In this study, we describe …

Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses,
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …

ABSTRACT N6-adenosine methylation (m6A) is the most common posttranscriptional RNA
modification in mammalian cells. We found that most transcripts encoded by the Kaposi's …

Herpesvirus latency is generally thought to be governed by epigenetic modifications, but the
dynamics of viral chromatin at early timepoints of latent infection are poorly understood …