Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …

The continued evolution of SARS-CoV-2 has led to the emergence of several new Omicron
subvariants, including BQ. 1, BQ. 1.1, BA. 4.6, BF. 7, and BA. 2.75. 2. Here, we examine the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …

The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

Summary Background Post-COVID-19 condition (also known as long COVID) is an
emerging chronic illness potentially affecting millions of people. We aimed to evaluate …

Background Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an
important component of the comprehensive response to the severe acute respiratory …

Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to
tackle disease-causing proteins that have historically been highly challenging to target with …

Abstract ChEMBL (https://www. ebi. ac. uk/chembl/) is a manually curated, high-quality, large-
scale, open, FAIR and Global Core Biodata Resource of bioactive molecules with drug-like …

Abstract The Reactome Knowledgebase (https://reactome. org), an Elixir core resource,
provides manually curated molecular details across a broad range of physiological and …