Nucleic acid is the main material for storing, copying, and transmitting genetic information.
Gene sequencing is of great significance in DNA damage research, gene therapy, mutation …

In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Background Molecular diagnostics are considered the most promising route to achievement
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex …

Tuberculosis remains the leading cause of death from an infectious disease worldwide.
Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis …

Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major
threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction …

The emergence of drug-resistant tuberculosis is a major global public health concern that
threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …

Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …

Drug resistance diagnostics that rely on the detection of resistance-related mutations could
expedite patient care and TB eradication. We perform minimum inhibitory concentration …

Highlights•Management of tuberculosis is complicated by high levels of drug resistance in
some regions of the world.•Increasingly, molecular diagnostics are being used for resistance …