The role of lipophagy in the development and treatment of non-alcoholic fatty liver disease

A Grefhorst, IP van de Peppel, LE Larsen… - Frontiers in …, 2021 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) or metabolic (dysfunction) associated liver
disease (MAFLD), is, with a global prevalence of 25%, the most common liver disorder …

Interplay between lipid metabolism, lipid droplets, and DNA virus infections

MA Farías, B Diethelm-Varela, AJ Navarro, AM Kalergis… - Cells, 2022 - mdpi.com
Lipid droplets (LDs) are cellular organelles rich in neutral lipids such as triglycerides and
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …

The role of altered lipid composition and distribution in liver fibrosis revealed by multimodal nonlinear optical microscopy

H Jia, J Liu, T Fang, Z Zhou, R Li, W Yin, Y Qian… - Science …, 2023 - science.org
Intracellular lipid accumulation is commonly seen in fibrotic livers, but its exact role in liver
fibrosis remains elusive. Here, we established a multimodal nonlinear optical microscopy to …

A near-infrared AIE probe and its applications for specific in vitro and in vivo two-photon imaging of lipid droplets

HF Su, QC Peng, YU Liu, T **e, PP Liu, YC Cai, W Wen… - Biomaterials, 2022 - Elsevier
Nearly all living cells of organisms, including animals, protists, plants, and microorganisms,
synthesize lipid droplets (LDs), in which cholesteryl esters and triacylglycerol are stored …

Quantification of lipid droplets polarity for evaluating non-alcoholic fatty liver disease via fluorescence lifetime imaging

C Lai, Y Zhao, X Zou, Y Liang, W Lin - Sensors and Actuators B: Chemical, 2022 - Elsevier
Lipid droplets (LDs) are a kind of subcellular organelle, and LDs' polarity is closely
associated with the initiation and development of non-alcoholic fatty liver disease (NAFLD) …

[HTML][HTML] Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD

H Li, Y Dun, W Zhang, B You, Y Liu, S Fu, L Qiu… - Life sciences, 2021 - Elsevier
Aim To emphasize the mechanism of the effect of exercise on lipid droplet (LD) metabolism
disorder in nonalcoholic fatty liver disease (NAFLD). Main methods C57BL/6J mice were …

Adaptive and maladaptive roles of lipid droplets in health and disease

JD Pressly, MZ Gurumani… - … of Physiology-Cell …, 2022 - journals.physiology.org
Advances in the understanding of lipid droplet biology have revealed essential roles for
these organelles in mediating proper cellular homeostasis and stress response. Lipid …

Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin

D Shan, J Wang, Q Di, Q Jiang, Q Xu - Food & Function, 2022 - pubs.rsc.org
Non-alcoholic fatty liver disease (NAFLD) has increasingly become a serious public health
problem. There is growing evidence that nonylphenol (NP) exposure may cause steatosis …

Emerging roles of calcium signaling in the development of non-alcoholic fatty liver disease

CC Chen, LW Hsu, KD Chen, KW Chiu… - International journal of …, 2021 - mdpi.com
The liver plays a central role in energy metabolism. Dysregulated hepatic lipid metabolism is
a major cause of non-alcoholic fatty liver disease (NAFLD), a chronic liver disorder closely …

Nobiletin mitigates NAFLD via lipophagy and inflammation

X Yang, Y Deng, Y Tu, D Feng, W Liao - Food & Function, 2022 - pubs.rsc.org
Nonalcoholic fatty liver disease (NAFLD), an increasingly serious health issue around the
world, is characterized as a lipid metabolic disorder without any satisfactory treatment …