Background and Purpose—The purpose of these guidelines is to provide an up-to-date
comprehensive set of recommendations in a single document for clinicians caring for adult …

Alteplase is currently the only approved thrombolytic agent for treatment of acute ischaemic
stroke, but interest is burgeoning in the development of new thrombolytic agents for systemic …

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A
Guideline for Healthcare Professionals From the American Heart Association/American Stroke …

Background and Purpose—The purpose of these guidelines is to provide an up-to-date
comprehensive set of recommendations for clinicians caring for adult patients with acute …

For over 40 years, attempts to develop treatments that protect neurons and other brain cells
against the cellular and biochemical consequences of cerebral ischaemia in acute …

While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

The advent of highly successful reperfusion provides the opportunity to consider novel
approaches to cytoprotection as adjunctive therapies. Several therapeutic targets for …

After ischaemic stroke, brain damage can be curtailed by rescuing the 'ischaemic penumbra'—
that is, the severely hypoperfused, at-risk but not yet infarcted tissue. Current evidence …

Neuroprotection remains one of the holy grails of acute ischemic stroke therapy. The ability
to protect the ischemic brain from injury until reperfusion and then to protect the brain from …

3414 Stroke December 2017 point of such trials would be the percentage of patients who
are thrombectomy candidates by accepted criteria on reaching the comprehensive stroke …