The endoplasmic reticulum (ER) represents the entry point into the secretory pathway where
nascent proteins encounter a specialized environment for their folding and maturation …

The concentration of Ca 2+ in the endoplasmic reticulum (ER) is critically important for
maintaining its oxidizing environment as well as for maintaining luminal ATP levels required …

Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase
(GCase), which cause Gaucher's disease, are the most frequent genetic risk factor for …

Neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by
the accumulation of insoluble protein aggregates in the brain. Proteostasis involves a …

Hsp70 chaperone machineries have pivotal roles in an array of fundamental biological
processes through their facilitation of protein folding, disaggregation, and remodeling. The …

Dysfunction of the endolysosomal system is implicated in the pathogenesis of both sporadic
and familial Parkinson disease (PD). Variants in genes encoding lysosomal proteins have …

Binding immunoglobulin protein (BiP), an essential and ubiquitous Hsp70 chaperone in the
ER, plays a key role in protein folding and quality control. BiP contains two functional …

Dopamine‐releasing neurons within the Substantia nigra (SN DA) are particularly
vulnerable to degeneration compared to other dopaminergic neurons. The age‐dependent …

Background Autosomal recessive mutations in the glucocerebrosidase gene, Beta‐
glucocerebrosidase 1 (GBA1), cause the lysosomal storage disorder Gaucher's disease …

The site of protein folding and maturation for the majority of proteins that are secreted,
localized to the plasma membrane or targeted to endomembrane compartments is the …