Adenosine and inflammation: here, there and everywhere
Adenosine is a ubiquitous endogenous modulator with the main function of maintaining
cellular and tissue homeostasis in pathological and stress conditions. It exerts its effect …
cellular and tissue homeostasis in pathological and stress conditions. It exerts its effect …
Regulation of microglial functions by purinergic mechanisms in the healthy and diseased CNS
P Illes, P Rubini, H Ulrich, Y Zhao, Y Tang - Cells, 2020 - mdpi.com
Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …
Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases
Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …
Danger signals in stroke and their role on microglia activation after ischemia
E Gülke, M Gelderblom… - Therapeutic advances in …, 2018 - journals.sagepub.com
Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen
and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular …
and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular …
Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
Adenosine receptor targets for pain
J Sawynok - Neuroscience, 2016 - Elsevier
The main focus for the development of adenosine targets as analgesics to date has been A
1 Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of …
1 Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of …
Microglia and the purinergic signaling system
Microglia are the main resident immune-competent cell type of the central nervous system
(CNS); these cells are highly sensitive to subtle changes in the chemical environment of the …
(CNS); these cells are highly sensitive to subtle changes in the chemical environment of the …
Molecular mechanisms of microglial motility: changes in ageing and Alzheimer's disease
Microglia are the tissue-resident immune cells of the central nervous system, where they
constitute the first line of defense against any pathogens or injury. Microglia are highly motile …
constitute the first line of defense against any pathogens or injury. Microglia are highly motile …
Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?
Introduction: The mechanism of sensitization of the central nervous system partly explains
the chronic pain experience in many patients, but the etiological mechanisms of this central …
the chronic pain experience in many patients, but the etiological mechanisms of this central …
Purinergic signaling orchestrating neuron-glia communication
P Agostinho, D Madeira, L Dias, AP Simões… - Pharmacological …, 2020 - Elsevier
This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …