Introduction confirmed this result and further revealed that in the Blood vessels are
fundamentally composed of endotheabsence of access to an adequate vasculature, tumor …

Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular
endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a …

In contrast with the prevailing view that most tumors and metastases begin as avascular
masses, evidence is presented here that a subset of tumors instead initially grows by …

Decades of efforts in engineering in vitro cancer models have advanced drug discovery and
the insight into cancer biology. However, the establishment of preclinical models that enable …

Recent studies of tissue culture cells have defined a widespread system of oxygen-
regulated gene expression based on the activation of a heterodimeric transcription factor …

Purpose: Tumor hypoxia adversely affects short term clinical radiation response of head and
neck cancer lymph node metastases and long term disease-free survival (DFS) in cervix …

Three-dimensional (3D) tissue culture models have an invaluable role in tumour biology
today providing some very important insights into cancer biology. As well as increasing our …

Mesenchymal stem cell (MSC)-based therapies are under broad investigation for
applications in tissue repair but suffer from poor cell persistence and engraftment upon …

Tissue hypoxia occurs where there is an imbalance between oxygen supply and
consumption. Hypoxia occurs in solid tumours as a result of an inadequate supply of …

The microenvironment within tumors is significantly different from that in normal tissues. A
major difference is seen in the chaotic vasculature of tumors, which results in unbalanced …