Therapeutic opportunities in inflammatory bowel disease: mechanistic dissection of host-microbiome relationships

DR Plichta, DB Graham, S Subramanian, RJ Xavier - Cell, 2019‏ - cell.com
The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …

[HTML][HTML] Polyamine and ethanolamine metabolism in bacteria as an important component of nitrogen assimilation for survival and pathogenicity

S Krysenko, W Wohlleben - Medical Sciences, 2022‏ - mdpi.com
Nitrogen is an essential element required for bacterial growth. It serves as a building block
for the biosynthesis of macromolecules and provides precursors for secondary metabolites …

Effects of polyethylene microplastics on the microbiome and metabolism in larval zebrafish

Y Zhao, Z Qin, Z Huang, Z Bao, T Luo, Y ** - Environmental Pollution, 2021‏ - Elsevier
Various microplastics (MPs) are found in the environment and organisms. MP residues in
organisms can affect health; however, their impacts on metabolism in aquatic organisms …

The novel genus, 'Candidatus Phosphoribacter', previously identified as Tetrasphaera, is the dominant polyphosphate accumulating lineage in EBPR wastewater …

CM Singleton, F Petriglieri, K Wasmund… - The ISME …, 2022‏ - academic.oup.com
The bacterial genus Tetrasphaera encompasses abundant polyphosphate accumulating
organisms (PAOs) that are responsible for enhanced biological phosphorus removal (EBPR) …

Genomic diversity landscape of the honey bee gut microbiota

KM Ellegaard, P Engel - Nature communications, 2019‏ - nature.com
The structure and distribution of genomic diversity in natural microbial communities is largely
unexplored. Here, we used shotgun metagenomics to assess the diversity of the honey bee …

Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use

U Kolli, R Jalodia, S Moidunny, PK Singh, Y Ban… - Gut …, 2023‏ - Taylor & Francis
Opioid crisis is an ongoing epidemic since the past several decades in the United States.
Opioid use-associated microbial dysbiosis is emerging as a key regulator of intestinal …

Mitochondria as intracellular signaling platforms in health and disease

JX Tan, T Finkel - Journal of Cell Biology, 2020‏ - rupress.org
Mitochondria, long viewed solely in the context of bioenergetics, are increasingly emerging
as critical hubs for intracellular signaling. Due to their bacterial origin, mitochondria possess …

Growth effects of N-acylethanolamines on gut bacteria reflect altered bacterial abundances in inflammatory bowel disease

N Fornelos, EA Franzosa, J Bishai, JW Annand… - Nature …, 2020‏ - nature.com
Inflammatory bowel diseases (IBD) are associated with alterations in gut microbial
abundances and lumenal metabolite concentrations, but the effects of specific metabolites …

Complex Bacterial Consortia Reprogram the Colitogenic Activity of Enterococcus faecalis in a Gnotobiotic Mouse Model of Chronic, Immune-Mediated Colitis

I Lengfelder, IG Sava, JJ Hansen, K Kleigrewe… - Frontiers in …, 2019‏ - frontiersin.org
Inflammatory bowel diseases (IBD) are associated with compositional and functional
changes of the intestinal microbiota, but specific contributions of individual bacteria to …

Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis

DR Plichta, J Somani, M Pichaud, ZS Wallace… - Genome medicine, 2021‏ - Springer
Background Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc)
are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in …