Due to worldwide demographic change, the number of older persons in the population is
increasing. Aging is accompanied by changes of sleep structure, deposition of beta-amyloid …

Abstract Purpose of Review To review methods for analyzing circadian rest-activity patterns
using actigraphy and to discuss their applications in large cohort and population-based …

Frailty is characterized by diminished resilience to stressor events. It is associated with
adverse future health outcomes and impedes healthy aging. The circadian system …

Background The relationship between 24-hour rest-activity rhythms (RARs) and risk for
dementia or mild cognitive impairment (MCI) remains an area of growing interest. Previous …

Hippocampal atrophy is a prominent neurodegenerative feature of Alzheimer's disease and
related dementias. Alterations in circadian rhythms can exacerbate cognitive aging and …

Abstract Purpose Frailty and Circadian Syndrome (CircS) are prevalent among the elderly,
yet the link between them remains underexplored. This study aims to examine the …

Chronic kidney disease (CKD) represents a significant global burden. Hypertension is a
modifiable risk factor for rapid progression of CKD. We extend the risk stratification by …

Background Postoperative delirium (POD) is prevalent in craniotomy patients and is
associated with high mortality. Sleep disturbances are receiving increasing attention from …

Background Many disease processes are influenced by circadian clocks and display~ 24‐
hour rhythms. Whether disruptions to these rhythms increase stroke risk is unclear. We …

Purpose Postoperative sleep disturbance, characterized by diminished postoperative sleep
quality, is a risk factor for postoperative delirium (POD); however, the association between …