The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics
on the market in Europe after 2013. In that context, the European Commission invited …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …

Currently, neurotoxicity testing defined by OECD and FDA is based solely on in vivo
experiments, using large numbers of animals, being expensive, time-consuming and …

Microelectrode array (MEA) approaches have been proposed as a tool for detecting
functional changes in electrically excitable cells, including neurons, exposed to drugs …

Testing of compounds for neurotoxicity has become increasingly important in recent years. It
has been shown that neurological disorders like autism may be related to chemical …

In 2006, the European Union (EU) promulgated a monumental regulatory initiative for the
Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH). To date …

Neuronal assemblies within the nervous system produce electrical activity that can be
recorded in terms of action potential patterns. Such patterns provide a sensitive endpoint to …

Planar microelectrode arrays (MEAs) are devices that can be used in biomedical and basic
in vitro research to provide extracellular electrophysiological information about biological …

We present a hiPSC-based 3D in vitro system suitable to test neurotoxicity (NT). Human
iPSCs-derived 3D neurospheres grown in 96-well plate format were characterized timewise …