The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …

By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …

The visualization of whole organs and organisms through tissue clearing and fluorescence
volumetric imaging has revolutionized the way we look at biological samples. Its application …

Increasingly, highly multiplexed tissue imaging methods are used to profile protein
expression at the single‐cell level. However, a critical limitation is the lack of robust cell …

Revealing the 3D composition of intact tissue specimens is essential for understanding cell
and organ biology in health and disease. State-of-the-art 3D microscopy techniques aim to …

Many solid tumors exhibit significant genetic, cellular, and biophysical heterogeneity which
dynamically evolves during disease progression and after treatment. This constant flux in …

Breast cancer is a pathological condition characterized by high morphological and
molecular heterogeneity. Not only the breast cancer cells, but also their tumor micro …

While the primary sequences of human proteins have been cataloged for over a decade,
determining how these are organized into a dynamic collection of multiprotein assemblies …

Lung cancer patients tend to have strong intratumoral and intertumoral heterogeneity and
complex tumor microenvironment, which are major contributors to the efficacy of and drug …

Achieving complete tumor resection is challenging and can be improved by real-time
fluorescence-guided surgery with molecular-targeted probes. However, pre-clinical …