Macrophages represent a major cell type of innate immunity and have emerged as a critical
player and therapeutic target in many chronic inflammatory diseases. Hepatic macrophages …

Autophagy, originally found in liver experiments, is a cellular process that degrades
damaged organelle or protein aggregation. This process frees cells from various stress …

Liver fibrosis represents a health problem with significant morbidity and mortality that affects
100 million people worldwide. It is a final pathway to several chronic liver diseases and is …

Macrophages are found in close proximity with collagen-producing myofibroblasts and
indisputably play a key role in fibrosis. They produce profibrotic mediators that directly …

Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis and inflammation
and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the …

The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

Loss of Hippo signaling in Drosophila leads to tissue overgrowth as a result of increased cell
proliferation and decreased cell death. YAP (a homolog of Drosophila Yorkie and target of …

The cellular oxidation and reduction (redox) environment is influenced by the production
and removal of reactive oxygen species (ROS). In recent years, several reports support the …

Increased attention is paid to the structural components of tissues. These components are
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …

Fatty liver disease comprises a spectrum ranging from simple steatosis to steatohepatitis
which can progress to liver cirrhosis and hepatocellular cancer. Hepatic lipotoxicity may …