Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-
associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas …

The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA …

Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …

Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …