The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …

Cannabinoids, the active components of cannabis (Cannabis sativa) extracts, have attracted
the attention of human civilizations for centuries, much earlier than the discovery and …

The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …

Changes in lipid metabolism are intimately related to cancer. Several classes of bioactive
lipids play roles in the regulation of signaling pathways involved in neoplastic transformation …

Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs),
namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 …

Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …

This review focuses on the role of the endocannabinoid signaling system in controlling
neuronal survival, an extremely important issue to be considered when develo** new …

The endocannabinoid system is known to regulate neural progenitor (NP) cell proliferation
and neurogenesis. In particular, CB 2 cannabinoid receptors have been shown to promote …

The purpose of this chapter is to provide an introduction to the mechanisms for the
regulation of endocannabinoid signaling through CB1 cannabinoid receptors in the central …