The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
The devastating clinical consequences of child abuse and neglect: increased disease vulnerability and poor treatment response in mood disorders
A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …
stage of development can have long-lasting consequences. It is associated with a marked …
Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes
Patients with major depressive disorder (MDD) exhibit concurrent deficits in both sensory
and higher-order cognitive processing. Connectome studies have suggested a principal …
and higher-order cognitive processing. Connectome studies have suggested a principal …
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice
Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for
psychiatric disorders including depression. In this study, we show that ELS in a postnatal …
psychiatric disorders including depression. In this study, we show that ELS in a postnatal …
Functional connectomics in depression: insights into therapies
Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …
behavioral symptoms. The emerging research paradigm of functional connectomics has …
Artificial intelligence applications in psychoradiology
One important challenge in psychiatric research is to translate findings from brain imaging
research studies that identified brain alterations in patient groups into an accurate diagnosis …
research studies that identified brain alterations in patient groups into an accurate diagnosis …
[HTML][HTML] Brain parcellation selection: An overlooked decision point with meaningful effects on individual differences in resting-state functional connectivity
Over the past decade extensive research has examined the segregation of the human brain
into large-scale functional networks. The resulting network maps, ie parcellations, are now …
into large-scale functional networks. The resulting network maps, ie parcellations, are now …
Parsing altered gray matter morphology of depression using a framework integrating the normative model and non-negative matrix factorization
S Han, Q Cui, R Zheng, S Li, B Zhou, K Fang… - Nature …, 2023 - nature.com
The high inter-individual heterogeneity in individuals with depression limits neuroimaging
studies with case-control approaches to identify promising biomarkers for individualized …
studies with case-control approaches to identify promising biomarkers for individualized …
Interactive relations between maternal prenatal stress, fetal brain connectivity, and gestational age at delivery
Studies reporting significant associations between maternal prenatal stress and child
outcomes are frequently confounded by correlates of prenatal stress that influence the …
outcomes are frequently confounded by correlates of prenatal stress that influence the …
On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations
Associations between datasets can be discovered through multivariate methods like
Canonical Correlation Analysis (CCA) or Partial Least Squares (PLS). A requisite property …
Canonical Correlation Analysis (CCA) or Partial Least Squares (PLS). A requisite property …