Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

C–H functionalization has been emerging as a powerful method to establish carbon–carbon
and carbon–heteroatom bonds. Many efforts have been devoted to transition-metal …

The development of catalytic enantioselective transformations, enabling the construction of
complex molecular scaffolds from simple precursors, has been a long-standing challenge in …

Although abundant in organic molecules, carbon–hydrogen (C–H) bonds are typically
considered unreactive and unavailable for chemical manipulation. Recent advances in C–H …

C–H functionalization has become widely recognized as an exciting new strategy for the
synthesis of complex molecular targets. Instead of relying on functional groups as the …

Natural enzymes contain highly evolved active sites that lead to fast rates and high
selectivities. Although artificial metalloenzymes have been developed that catalyze …

The dawn of the 21st century has brought with it a surge of research related to computer-
guided approaches to catalyst design. In the past two decades, chemoinformatics, the …

C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …

The insertion of carbenes into the α-C–H bonds of ethers represents one of the most
powerful approaches to access polysubstituted α-branched ethers. However, intermolecular …

The introduction of fluoroalkyl groups into organic compounds can significantly alter
pharmacological characteristics. One enabling but underexplored approach for the …