Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …

Meningeal lymphatic vessels have been described in animal studies, but limited comparable
data is available in human studies. Here we show dural lymphatic structures along the dural …

Paravascular drainage of solutes, including β-amyloid (Aβ), appears to be an important
process in brain health and diseases such as Alzheimer's disease (AD) and cerebral …

How aging affects cells of the human brain active milieu remains largely unknown. Here, we
analyze astrocytes and neurons in the neocortical tissue of younger (22–50 years) and older …

Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and
through the brain transports not only those water-like fluids but also any solutes they carry …