Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens?

RG Kenny, CJ Marmion - Chemical reviews, 2019 - ACS Publications
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

Platinum-containing heterometallic complexes in cancer therapy: advances and perspectives

L Ma, L Li, G Zhu - Inorganic Chemistry Frontiers, 2022 - pubs.rsc.org
Platinum-based anticancer drugs are among the most widely used antineoplastics in clinical
settings. Their therapeutic applications and outcomes are, however, greatly hampered by …

Ruthenium (II) polypyridyl complexes as FRET donors: structure-and sequence-selective DNA-binding and anticancer properties

CE Elgar, NA Yusoh, PR Tiley… - Journal of the …, 2023 - ACS Publications
Ruthenium (II) polypyridyl complexes (RPCs) that emit from metal-to-ligand charge transfer
(MLCT) states have been developed as DNA probes and are being examined as potential …

Construction of homo and heteronuclear Ru (II), Ir (III) and Re (I) complexes for target specific cancer therapy

S Pete, N Roy, B Kar, P Paira - Coordination Chemistry Reviews, 2022 - Elsevier
More than 10 million death tolls in 2020 were reported as a result of heinous impact of
cancer, making it second most prime cause of death after cardiovascular diseases. In …

Heterometallic supramolecular polymers: From synthesis to properties and applications

MK Bera, S Sarmah, DC Santra, M Higuchi - Coordination Chemistry …, 2024 - Elsevier
Heterometallic supramolecular polymers (HMSPs) comprising two or more heterometal ions
have drawn significant research interest in the last two decades because of their attractive …

A dinuclear ruthenium (II) complex excited by near-infrared light through two-photon absorption induces phototoxicity deep within hypoxic regions of melanoma cancer …

A Raza, SA Archer, SD Fairbanks… - Journal of the …, 2020 - ACS Publications
The dinuclear photo-oxidizing RuII complex [{Ru (TAP2)} 2 (tpphz)] 4+(TAP= 1, 4, 5, 8-
tetraazaphenanthrene, tpphz= tetrapyrido [3, 2-a: 2′, 3′-c: 3 ″, 2′′-h: 2‴, 3′′′-j] …

Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs: A review

P Sudhindra, SA Sharma, N Roy, P Moharana, P Paira - Polyhedron, 2020 - Elsevier
Due to these limitations of platinum-based drugs, it has now become a challenge for
researchers to find out a potential scaffold furnished with indispensable properties like …

Exploring the cytotoxicity, uptake, cellular response, and proteomics of mono-and dinuclear DNA light-switch complexes

PJ Jarman, F Noakes, S Fairbanks… - Journal of the …, 2018 - ACS Publications
Drug resistance to platinum chemotherapeutics targeting DNA often involves abrogation of
apoptosis and has emerged as a significant challenge in modern, non-targeted …

Using nanoscopy to probe the biological activity of antimicrobial leads that display potent activity against pathogenic, multidrug resistant, gram-negative bacteria

KL Smitten, HM Southam, JB de la Serna, MR Gill… - ACS …, 2019 - ACS Publications
Medicinal leads that are also compatible with imaging technologies are attractive, as they
facilitate the development of therapeutics through direct mechanistic observations at the …

Editorial of special issue ruthenium complex: The expanding chemistry of the ruthenium complexes

I Dragutan, V Dragutan, A Demonceau - Molecules, 2015 - mdpi.com
Molecules | Free Full-Text | Editorial of Special Issue Ruthenium Complex: The Expanding
Chemistry of the Ruthenium Complexes Next Article in Journal The Guareschi Pyridine …