[HTML][HTML] Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential

H Kheraldine, O Rachid, AM Habib… - Advanced drug delivery …, 2021 - Elsevier
Drug delivery systems or vectors are usually needed to improve the bioavailability and
effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an …

[HTML][HTML] Safety challenges and application strategies for the use of dendrimers in medicine

X Li, A Naeem, S **ao, L Hu, J Zhang, Q Zheng - Pharmaceutics, 2022 - mdpi.com
Dendrimers are used for a variety of applications in medicine but, due to their host–guest
and entrapment characteristics, are particularly used for the delivery of genes and drugs …

[HTML][HTML] Cytotoxic potential and molecular pathway analysis of silver nanoparticles in human colon cancer cells HCT116

S Gurunathan, M Qasim, C Park, H Yoo, JH Kim… - International journal of …, 2018 - mdpi.com
Silver nanoparticles (AgNPs) have gained attention for use in cancer therapy. In this study,
AgNPs were biosynthesized using naringenin. We investigated the anti-colon cancer …

Layered Double Hydroxide Modified Bone Cement Promoting Osseointegration via Multiple Osteogenic Signal Pathways

Y Wang, S Shen, T Hu, GR Williams, Y Bian, B Feng… - ACS …, 2021 - ACS Publications
Poly (methyl methacrylate)(PMMA) bone cement has been widely used in orthopedic
surgeries including total hip/knee replacement, vertebral compression fracture treatment …

Co-delivery of sorafenib and CRISPR/Cas9 based on targeted core–shell hollow mesoporous organosilica nanoparticles for synergistic HCC therapy

BC Zhang, BY Luo, JJ Zou, PY Wu… - … Applied Materials & …, 2020 - ACS Publications
The rapid development of CRISPR/Cas9 systems has opened up tantalizing prospects to
sensitize cancers to chemotherapy using efficient targeted genome editing, but safety …

Dendrimers as modifiers of inorganic nanoparticles for therapeutic delivery in cancer

M Zenze, A Daniels, M Singh - Pharmaceutics, 2023 - mdpi.com
The formulation of nanoscale systems with well-defined sizes and shapes is of great interest
in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are …

PAMAM dendrimer nanomolecules utilized as drug delivery systems for potential treatment of glioblastoma: a systematic review

M Fana, J Gallien, B Srinageshwar… - International journal …, 2020 - Taylor & Francis
Glioblastoma (GB) is a grade IV astrocytoma that maintains a poor prognosis with respect to
current treatment options. Despite major advancements in the fields of surgery and …

Mechanistic insights into the biological effects of engineered nanomaterials: a focus on gold nanoparticles

NHA Nguyen, P Falagan-Lotsch - International Journal of Molecular …, 2023 - mdpi.com
Nanotechnology has great potential to significantly advance the biomedical field for the
benefit of human health. However, the limited understanding of nano–bio interactions …

Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems

K Dua, V Malyla, G Singhvi, R Wadhwa… - Chemico-biological …, 2019 - Elsevier
Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory
diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD) …

High throughput toxicity screening and intracellular detection of nanomaterials

AR Collins, B Annangi, L Rubio… - Wiley …, 2017 - Wiley Online Library
With the growing numbers of nanomaterials (NMs), there is a great demand for rapid and
reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical …