Single-cell RNA-seq methods to interrogate virus-host interactions
The twenty-first century has seen the emergence of many epidemic and pandemic viruses,
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has high relapse and low 5-year survival rates. Single-cell
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
E Madissoon, A Wilbrey-Clark, RJ Miragaia… - Genome biology, 2020 - Springer
Abstract Background The Human Cell Atlas is a large international collaborative effort to
map all cell types of the human body. Single-cell RNA sequencing can generate high-quality …
map all cell types of the human body. Single-cell RNA sequencing can generate high-quality …
High throughput single cell RNA sequencing, bioinformatics analysis and applications
Single cell sequencing (SCS) can be harnessed to acquire the genomes, transcriptomes
and epigenomes from individual cells. Next generation sequencing (NGS) technology is the …
and epigenomes from individual cells. Next generation sequencing (NGS) technology is the …
Clonal decomposition and DNA replication states defined by scaled single-cell genome sequencing
Accurate measurement of clonal genotypes, mutational processes, and replication states
from individual tumor-cell genomes will facilitate improved understanding of tumor evolution …
from individual tumor-cell genomes will facilitate improved understanding of tumor evolution …
Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites
Single-cell RNA-sequencing is revolutionising our understanding of seemingly
homogeneous cell populations but has not yet been widely applied to single-celled …
homogeneous cell populations but has not yet been widely applied to single-celled …
Multiregion single‐cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancer
W Wang, Y Zhong, Z Zhuang, J **e, Y Lu… - Clinical and …, 2021 - Wiley Online Library
The tumor microenvironment is a complex ecosystem formed by distinct and interacting cell
populations, and its composition is related to cancer prognosis and response to clinical …
populations, and its composition is related to cancer prognosis and response to clinical …
[HTML][HTML] The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring
PMK Tang, S Zhou, CJ Li, J Liao, J **ao, QM Wang… - Kidney international, 2018 - Elsevier
Src activation has been associated with fibrogenesis after kidney injury. Macrophage-
myofibroblast transition is a newly identified process to generate collagen-producing …
myofibroblast transition is a newly identified process to generate collagen-producing …
The determinants of alternative RNA splicing in human cells
Alternative splicing represents an important level of the regulation of gene function in
eukaryotic organisms. It plays a critical role in virtually every biological process within an …
eukaryotic organisms. It plays a critical role in virtually every biological process within an …
Clinically relevant fusion oncogenes: Detection and practical implications
M Sorokin, E Rabushko… - Therapeutic …, 2022 - journals.sagepub.com
Mechanistically, chimeric genes result from DNA rearrangements and include parts of
preexisting normal genes combined at the genomic junction site. Some rearranged genes …
preexisting normal genes combined at the genomic junction site. Some rearranged genes …