Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Stress is associated with obesity, and the neurobiology of stress overlaps significantly with
that of appetite and energy regulation. This review will discuss stress, allostasis, the …

Obesity and mood disorders are highly prevalent and co-morbid. Epidemiological studies
have highlighted the public health relevance of this association, insofar as both conditions …

An increasingly influential perspective conceptualizes both obesity and overeating as a food
addiction accompanied by corresponding brain changes. Because there are far-reaching …

The US remains at the forefront of a global obesity epidemic with a significant negative
impact on public health. While it is well known that a balance between energy intake and …

Over the past few years, evidence has accumulated that the human brain is an insulin-
sensitive organ. Insulin regulates activity in a limited number of specific brain areas that are …

The hedonic properties of food can stimulate feeding behaviour even when energy
requirements have been met, contributing to weight gain and obesity. Similarly, the hedonic …

Background Obesity has been linked with subtle differences in brain structure. These
differences tend to be especially relevant in prefrontal cortex regions, areas which play an …

OBJECTIVE Obesity is associated with alterations in corticolimbic-striatal brain regions
involved in food motivation and reward. Stress and the presence of food cues may each …

The functional MRI (fMRI) community has zealously embraced resting state or intrinsic
functional connectivity approaches to map** brain organization. Having demonstrated …