The prevalence of neurodegenerative disorders such as Parkinson's disease are increasing
as world populations age. Despite this growing public health concern, the precise molecular …

Limited understanding of regulatory mechanisms controlling LRRK2 kinase activity has
hindered insights into both its normal biology and how its dysregulation contributes to …

Cytopathology induced by methamphetamine (METH) is reminiscent of degenerative
disorders such as Parkinson's disease, and it is characterized by membrane organelles …

Mounting evidence supports a critical role for central nervous system (CNS) glial cells in
neuroinflammation and neurodegenerative diseases, including Alzheimer's disease (AD) …

Parkinson disease-causing mutations in the LRRK2 gene hyperactivate LRRK2 kinase
activity, leading to increased phosphorylation of a subset of RAB GTPases, which are master …

Mutations in leucine-rich repeat kinase 2 (LRRK2) that increase its kinase activity are
strongly linked to genetic forms of Parkinson's disease (PD). However, the regulation of …

Parkinson's Disease (PD) pathologically defined by the accumulation of alpha-synuclein (α-
syn) aggregates and selective loss of dopaminergic neurons is the most common …

Parkinson's disease (PD) is a neurodegenerative disease characterized by dopaminergic
neuron loss in the substantia nigra. The incidence of the disease, which has symptoms such …

Für die pharmakologische Behandlung der Parkinson-Erkrankung stehen aktuell
ausschliesslich symptomatische Therapieansätze zur Verfügung. Obwohl inzwischen …