The linker histone H1 family members are a key component of chromatin and bind to the
nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both …

Understanding how the genome is structurally organized as chromatin is essential for
understanding its function. Here, we review recent developments that allowed the …

HP1 proteins are central to the assembly and spread of heterochromatin containing histone
H3K9 methylation. The chromodomain (CD) of HP1 proteins specifically recognizes the …

Publisher Summary This chapter summarizes recent information on the function of high-
mobility-group (HMG) proteins. Advances in this field were made primarily by elucidating the …

The chromatin structure of yeast ribosomal DNA was analyzed In vivo by crosslinklng Intact
cells with psoralen. We found that In exponentially growing cultures the regions coding for …

Positioned nucleosomes limit the access of proteins to DNA and implement regulatory
features encoded in eukaryotic genomes. Here we have generated the first genome-wide …

▪ Abstract The substrates for the essential biological processes of transcription, replication,
recombination, DNA repair, and cell division are not naked DNA; rather, they are protein …

Rat liver interphase chromosomes have telomeres 20-100 kb in length. Micrococcal
nuclease digestion of nuclei cleaves telomeres with a uniform 157 bp periodicity, producing …

Ever since the discovery of the nucleosome in 1974, scientists have stumbled upon discrete
particles in which DNA is wrapped around histone complexes of different stoichiometries …

Through dynamic changes in structure resulting from DNA–protein interactions and
constraints given by the structural features of the double helix, chromatin accommodates …